GW501516 (also known as GW-501,516, GW1516, GSK-516 and Endurobol) is a PPARδ receptor. It activates the same pathways activated through exercise, It had been investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. GW501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone.
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